Downregulation of BCL2 by miRNAs augments drug induced apoptosis: Combined computational and experimental approach
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Downregulation of BCL2 by miRNAs augments drug-induced apoptosis--a combined computational and experimental approach.
A number of anti-cancer strategies aim to target the mitochondrial apoptotic machinery to induce tumour cell death. Mitochondria play a key role as death amplifiers by releasing apoptogenic factors from the mitochondrial inter-membrane space into the cytosol. BCL2 proteins are known for their ability to regulate both mitochondrial physiology and cell death, and their deregulated expression ofte...
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